Biology 113
Fall 2001
Lecture outline 8
9/12/01
Prions (continued)
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Mad cow and related diseases
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Experimental evidence for protein rather than nucleic acid as the source
of infectivity
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The prion protein, conformational change as basis for the disease
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Many questions remain
Cell signaling - overview
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importance of protein shape and structure
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importance of the membrane
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importance of proper protein localization
Biochemical bonds
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covalent
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polar covalent
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hydrogen bonds
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ionic bonds
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van der Waals and hydrophobic interactions
Amino acid structure - function.
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Basic structure
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R groups
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charge
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hydrophobicity
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size/bulk
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