KAP Genetics and Development
|
Fall Semester 2004
Last modified 11/19/04 Latest update overrides all previous versions (electronic and print). MWF 11:10
AM-12:00 Noon (Period 4) Dr. Wade Powell FSH 202, x5396 powellw@kenyon.edu Office hours: Mondays 3-5 PM; Tuesdays 3-4 PM; Thursdays 9-11 AM (and by appointment) Visitors: Please report corrections to course directors. Linked articles: Only viewed at Kenyon. This course introduces the mechanisms of heredity, the expression of genetic information, and the genetic control of development. Genetics and development are part of a continuous process revealing a fundamental kinship of life on earth.
How to do well in this course.
Grades. Grades are based on:
Academic Honesty.
This class will follow the official Kenyon College position on academic
honesty. It is your responsibility to review the official College policy on
academic honesty and adhere to this policy. Special Needs.
For assistance related to a physical, psychological or learning
disability that may impact your ability to participate fully in the
course, please speak with the instructor and with Erin Salva,
Coordinator of Disability Services (PBX 5453; salvae@kenyon.edu). All
information and documentation of disability is confidential. Please see
the Disability Services web
site for more information. |
DATE | TOPIC & WEBNOTES links | READING -- Color coded |
Aug
30
|
Course
introduction; history
of genetics; genes and genomes.
|
|
Sept. 1 | DNA structure | Ch. 3 pp. 47-48 and 59-62; errors in text; Classic papers |
Sept. 3 | DNA replication; PCR; DNA sequencing; QUIZ 1 | Ch. 12 pp. 232-244, Activities 12.1, 12.2 |
Sept. 6 |
Ch. 15 p. 298-299 (Fig. 15.3) |
|
Sept. 8 | Meiosis | Ch. 8 pp. 155-164; Ch. 9 pp. 176-193; Activities 8.2, 9.1 |
Sept. 10 |
Mendelian inheritance |
Ch. 10 pp. 194-205; Activities
10.1, 10.2. Dihybrid
Cross; Download Flowers |
Sept.
13
|
Ch. 10 pp. 206-207;Ch. 17 pp. 339-341; X and Y |
|
Sept.
15
|
Recombination and gene mapping | Ch. 10 pp 207-209; Linkage |
Sept. 17 | Gene product interactions; non-Mendelian genetics QUIZ 3 | Ch. 10 pp. 209-214 |
Sept. 20 | Genetics Catch-up | More practice problems |
Sept. 22 | EXAM 1 (score distribution) | ---------- |
Sept. 24 |
Ch. 11, pp. 217-220
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|
Sept. 27 |
Ch. 11, pp. 220-223; Ch.
13 252-256; Activity 13.1; Activity 11.1
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|
Sept.
29
|
Ch. 11, pp. 223-227; Activity
11.2
|
|
Oct. 1 | Translation. QUIZ 4 | Ch. 13, pp. 259-270; Activity 13.2 |
Oct. 4 | Eukaryotic transcription and splicing | Ch. 13, pp. 256-259 |
Oct.
6
|
Ch. 12, pp. 243-249; RNA
Editing
|
|
Oct. 8 |
Applying Central Dogma Concepts I: Regulation of the eukaryotic cell cycle. QUIZ 5 |
Ch. 8, pp. 155-159 and 164-173; Activity 8.1; |
Oct. 11 |
NO CLASS: October Reading Days |
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Oct.
13
|
Cell cycle and cancer | Smoking and Lung Cancer |
Oct. 15 |
Ch. 46, pp. 891-911
|
|
Oct. 18 | EXAM 2 (score distribution) | ------- |
Oct.
20
|
Problems and
Approaches I: 1. PCR: Making lots of DNA from just a little.and DNA 2. How to determine the sequence of a DNA molecule |
Ch. 12 pp. 240-243, Activities 12.1, 12.2 |
Oct. 22 | Problems and Approaches II: Measuring Gene Expression: northern blots, RT-PCR, western blots, cDNA microarrays. | Ch. 15 pp. 308-309; Ch. 16 pp. 320-330; DNA Chip |
Oct. 25 | Problems and Approaches III: Customizing DNA molecules. Recombinant DNA, transgenic organisms, and gene therapy | Ch. 3, pg. 50; Ch. 15, pp. 308-309; Ch. 17 pp. 339 - 345;Ch. 15, pg. 302; Ch. 17 pp. 335-339 & 345 - 351; Activity 17.1; Plasmid (downloaded with Flowers) |
Oct.
27
|
Prokaryotic
Gene Expression I: Operons
Two take-home quizzes are due Monday November 1. Download here: QUIZ 6 & QUIZ 7. |
Ch. 14, pp. 274-295 |
Oct. 29 |
Prokaryotic Gene Expression II: Operon Analysis; Regulons, Promoters |
Ch. 14, pp. 274-295; Activity 14.1 |
Nov. 1 |
Ch. 15 pp. 296-305 |
|
Nov.
3
|
Ch. 15 pp. 305--307
|
|
Nov. 5 | Eukaryotic
Gene Expression III: Nucleosomes and transcription; post-transcriptional regulation QUIZ 8 |
Ch. 15 pp. 298-300; Activity 15.1 |
Nov. 8 | Junk DNA? non-coding RNAs and gene expression | RNAi and riboswitches: Gibbs
(2003) Scientific American article (local access only) RNAi article from The Scientist |
Nov. 10 | EXAM 3 (score distribution) | ---------------------------- |
Nov. 12 |
Ch. 18 pp. 354-360; Activity 18.1
Ch. 18 pp. 361-368; Signals |
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Nov. 15 | Microbial development and more microbial development; | Heterocysts |
Nov. 17 |
Ch. 18, pp. 355-356; Ch. 19,
pp. 379-380; Ch. 20 pp. 399-402
|
|
Nov. 19 | Fertilization and Cleavage in animals; QUIZ 9 | Ch. 19, pp. 370-382 |
THANKSGIVING BREAK
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Nov. 29 | Cell Movement and Gastrulation. |
Ch. 19 pp. 382-389; Activity 19.1 |
Dec. 1 |
Organizing
the embryo;
|
Ch. 19 pp. 383-389 |
Dec.
3
|
Pattern formation in Animals; QUIZ 10
|
Ch. 20 pp. 391-399; Activity 20.1; Animated tutorial
|
Dec. 6 | Hox Genes; Gene/Genome Duplication and Molecular Evolution | Ch. 20 pp. 396-399; Ch. 24 pp. 473-476. C. elegans, Twinned genes |
Dec. 8 | Cell Differentiation: Neurulation and organogenesis. | Ch. 20 pp. 402-409 |
Dec.
10
|
Special Topic: Embryonic Stem Cells and Human Cloning | Ch. 20 pp. 406-407 |
Dec. 13 | EXAM 4 | ------------ |
Dec. 20** | OPTIONAL FINAL EXAM AT 8:30 AM | **This is a MONDAY MORNING** |