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BIOL 321 Developmental
Biology
Spring
2004
Schedule
Course Description
This advanced* course concerns the mechanisms responsible for building multicellular organisms, including vertebrates, invertebrates, and plants. The processes of fertilization, embryogenesis, and post-embryonic development will be examined at the molecular and cellular levels. Particular attention will be devoted to the experimental basis for current models of these processes. Students will read original research literature as well as standard texts. Prerequisites: BIOL 113 and 114.
*knowledge of material covered in Biology 114 (Genetics and Development of Organisms) is assumed. Please review the webnotes and/or see me if you require help with this material.
Reading
Required textbook: Principles of Development, Wolpert, et al. 2002
Journal articles will be available on the internet and/or the P drive.
Course requirements and grading scheme
Class attendance and participation are a critical part of your responsibility in this course, and will be included in determining your grade in the course (see below). To participate intelligently in class, it is essential that you read and thoughtfully consider the assigned material before each class.
Evaluation of your performance in this class will include both a measurement of understanding of the material and processes that form the content of the course and the clarity of presentation in written or oral form. Your course grade will be determined as follows:
Six 15 minute in-class quizzes, lowest score will be dropped 15%One take-home midterm examination (due Friday, March 5 by 4 PM) 15%
One take-home final examination (due Saturday, May 15 by 11 AM) 20%
One grant proposal project 25%
4-6 page critique of recent journal article (due Monday, February 23 at 4 PM) Leadership of class discussions on journal articles 10%Outline of grant proposal (due Monday, March 29 at 4 PM) Grant proposal (due Monday, April 19 at 4 PM)
Peer-review of two grant proposals (due Monday, April 26 at 4 PM)
Grant proposal resubmission (due Monday, May 3 at 4 PM)
Class participation - includes attendance, regular participation in class discussions, 15%
and occasional homework assignments.
Academic honesty
I strongly encourage you to exchange information, discuss class material, and bounce ideas off of one another (and me). However, all work submitted for evaluation must be your own. Please review the College policy on academic honesty, and ask if you have questions!
Disabilities
If you have a disability and therefore may need some
type of accommodation(s) in order to participate fully in this class,
please feel free to discuss your concerns in private with me AND
be sure to contact Erin Salva, Coordinator of Disability Services at PBX
5453 or via e-mail at SALVAE.
This schedule is tentative and is subject to change
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TOPIC | READING | ASSIGNMENTS |
Jan 22 |
Introduction to course; history, concepts,
model organisms
control of gene expression |
1-57 295-304 |
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Jan 29 |
Identifying developmental genes
Vertebrate dev.: axes |
58-63; journal article
(led by KH)
65-82 |
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Feb 5 |
Vertebrate dev.: axes
no class |
journal article (led by James, Carolyn and Callie) |
Quiz 1 (2/3) |
Feb 12 |
Vertebrate dev.: germ layers
CLASS CANCELLED; make-up next
week at KAH's house |
83-105
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Feb 17 evening Feb 19 |
Vertebrate dev.: somites
Vertebrate dev.: germ layers
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109-125
journal article (led by Andy, Lizzy and Linda) journal article (led by Michael, Sam and Cullen) |
Quiz 2 (2/17) |
Feb 26 |
Vertebrate dev.: neural induction
Vertebrate dev.: neural induction |
125-139
journal article (led by Phil and Amy) |
journal article critique due 2/23 at
4 PM
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Mar 4 |
Fly dev.: body axes
Fly dev.: body axes |
143-165
journal article (led by KH) |
Quiz 3 (3/2) |
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Mar 25 |
Fly dev.: segmentation
Nematode dev. |
166-188 191-201 |
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Apr 1 |
Plant dev.
Plant dev. |
journal article
(led by Jamie, Mike and Porsche), 221-231
journal article (led by Bethany, Kate and Emmie, available at P:/data/biology/biol321/040104), 232-242 |
Outline for grant proposal due 3/29 at 4 PM
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Plant dev.
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243-250
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Pre-proposal conferences
by 4 PM 4/5 |
Apr 15 |
Morphogenesis
Morphogenesis |
281-290
journal article; be sure to look at supplementary data/movies |
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Apr 22 |
Differentiation
Differentiation |
293-294, 304-327
journal article |
Grant proposal
due 4/19 at 4 PM
Grant panel
meetings this weekQuiz 5 (4/20) |
Apr 29 |
Organogenesis
Organogenesis |
331-350
350-370, journal article |
Peer-review of grant proposals due 4/26 at 4 PM |
May 6 |
Evolution of development
Evolution of development |
493-511, review
article
511-518 |
Resubmission of grant proposal due 5/3 at 4 PM Quiz 6 (5/4) |
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Take home final exam due 5/15 at 11 AM |
Links:
More wnt/wingless
movies
Zebrafish
somitogenesis movie
in situ hybridization from lab class
last updated 4/14/04