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BIOL 321 Developmental
Biology
Schedule
Course Description
This advanced* course concerns the molecular and cellular mechanisms responsible for building multicellular organisms, including vertebrates, invertebrates and plants. Students will read and discuss original research literature as well as standard texts. Prerequisites: BIOL 113 (6/13) and 114 (7/14).
*knowledge of material covered in Biology 7/14/114 (Intro to Genetics and Development) is assumed. Please review the webnotes and/or see me if you require help with this material.
Reading
Required textbook: Principles of Development, Wolpert, et al. 1998
Journal articles will be available on the internet, the P drive and/or ERES.
Course requirements and grading scheme
Class attendance and participation are a critical part of your responsibility in this course, and will be included in determining your grade in the course (see below). To participate intelligently in class, it is essential that you read and thoughtfully consider the assigned material before each class.
Evaluation of your performance in this class will include both a measurement of understanding of the material and processes that form the content of the course and the clarity of presentation in written or oral form. Your grade will be determined by a 1000 point scale as follows:
Seven 30 point quizzes, lowest two scores will be dropped = 150 points (in class, 15 min. each)One 150 point take-home midterm examination (due March 2 in class)
One 200 point take-home final examination (due May 11 at 5 pm)
One 270 point grant proposal project
Leadership of two class discussions on journal articles, 40 points each = 80 points 4-6 page critique of recent journal article 70 points (due February 19) Outline of grant proposal 30 points (due March 22)
First draft of grant proposal 70 points (due April 19)
Final draft of grant proposal 100 points (due May 4)
150 points of class participation - includes attendance, regular participation in class discussions, and occasional homework assignments.
Academic
honesty
I strongly encourage you to exchange information, discuss class material, and bounce ideas off of one another (and me). However, all work submitted for evaluation must be your own. Please review the College policy on academic honesty (pp 27-30 of the Course of Study), and ask if you have questions!
Disabilities
If you have a disability and therefore may need some
type of accommodation(s) in order to participate fully in this class, please
feel free to discuss your concerns in private with me AND be sure
to contact Erin Salva, Coordinator of Disability Services at PBX 5453 or
via e-mail at SALVAE.
This schedule is tentative and
is subject to change
|
TOPIC | READING (in Wolpert unless otherwise noted) | ASSIGNMENTS |
Jan 17 Jan 19 |
Introduction
and course requirements, history, concepts
A conceptual toolkit (review) Differential gene expression |
1-9
9-22 281-286 |
|
Jan 24 Jan 26 |
Identifying developmental
genes
Model organisms: vertebrates Vertebrate dev: Axes I |
23-24, 52-58
25-43 61-66 |
Quiz 1 (1/26) |
Jan 31 Feb 2 |
Vertebrate dev: Axes
II
Vertebrate dev: Axes III Vertebrate dev: Germ Layers I |
66-75
journal article (discussion led by KH)
|
|
Feb 7 Feb 9 |
Vertebrate dev: Germ
Layers II
Vertebrate dev: Germ Layers III Vertebrate dev: Somite formation |
-------
journal article (discussion led by Sarah) 97-110 |
journal article for critique to be
approved by 2/7
Quiz 2 (2/9) |
Feb 14 Feb 16 |
Vertebrate dev: Neural
induction
Vertebrate dev: Neural induction Vertebrate dev. |
110-122
------- journal article (discussion led by Angela) |
|
Feb 21 Feb 23 |
Model organisms: invertebrates
Fly embyogenesis I Fly embyogenesis II |
43-49
125-138 139-146 |
journal
article critique due 2/19 in class
Quiz 3 (2/23) |
Feb 28 Mar 2 |
Fly embyogenesis III
Fly embyogenesis IV Fly embyogenesis V |
146-161
161-167 journal article (discussion led by KH) |
Take home midterm exam due 3/2 in class |
|
|||
Mar 21 Mar 23 |
Nematode development I
Nematode development II
Model organisms: plants |
171-180
journal article (discussion led by Mike)
49-51, review article |
Outline for grant
proposal due 3/22 by 10 am
Quiz 4 (3/23) |
Mar 28 Mar 30 |
Plant development: embryogenesis
Plant development: meristems Plant development: flowers |
203-213
213-221 221-228 |
Pre-proposal conferences by 4 pm 3/28 |
Apr 4 Apr 6 |
Plant development
Morphogenesis I Morphogenesis II |
journal article (discussion led by KH)
231-242 242-253 |
Quiz 5 (4/6) |
Apr 11 Apr 13 |
Morphogenesis III
Morphogenesis IV Morphogenesis V |
journal article (discussion led by Sarah)
254-265 journal article (discussion led by Angela) |
|
Apr 18 Apr 20 |
Cell differentiation I
Cell differentiation II Cell differentiation III |
269-286 (review 281-286)
287-300 -------- |
Grant proposal
due 4/19 by 10 am
Quiz 6 (4/20) |
Apr 25 Apr 27 |
Cell differentiation IV
Organogenesis I Organogenesis II |
journal article (discussion led by Mike)
303-319 320-327 |
|
May 2 May 4 |
Organogenesis
III
Organogenesis IV Evolution of development |
328-336
journal article (discussion led by KH) 443-461 |
Resubmission of
grant proposal due 5/4 by 5 pm
Quiz 7 (5/4) |
|
Take home final exam due 5/11 by 5 pm |
Links: