 
 
    
| BIOL 
          333  Environmental Toxicology | Spring 
          Semester 2003  Tuesday 
          & Thursday | |
|  | 
Primary Literature and journalistic 
      sources: Articles on the BIOL 
      333 e-res course page and handouts in class.
      
      Scientific Text: CH Walker, SP Hopkin, RM Sibly, and DB Peakall (2001) 
      Principles of Ecotoxicology, 2nd edition (available at Kenyon bookstore)
      
      Popular Press: T. Colburn, D. Dumanoski, and JP Myers (1996) Our 
      Stolen Future (available 
      at Kenyon bookstore)
      
      All reading assignments must be completed before the date indicated on the 
      syllabus.
Policies and Expectations:
      
      Class attendance: 100% attendance is expected, and absences will 
      detract from one's grade. Please see me immediately about conflicts due 
      to sports events, performances, etc.
Class participation: To 
      participate fully in class,you must thoughtfully read the assigned material 
      before each meeting. Intelligent, vocal participation in class will be a 
      primary determinant of class participation grade, although other types of 
      contributions will also be recognized. Please feel free to ask questions, 
      add insights, correct the instructor's innacuracies, etc . at any time during 
      class
      
      Scheduling and Deadlines. Please plan carefully. Exam schedules and 
      deadlines for submitting assigned work are firm, and extensions will not 
      be granted for conflcits with the workload for other courses. Accomodations 
      due to illness or other personal situation must be requested and negotiated 
      through the Dean of Students or the Health and Counseling Center. 
      
      Academic Honesty. Do not lie, cheat, or plagiarize. Do your own work 
      on exams, properly cite your sources of information, and acknowledge the 
      help you receive from others. Kenyon's policy on academic honesty will be 
      strictly observed (see Kenyon College Course of Study, pp. 26 - 29 or on-line). 
      Explicit guidelines relating to projects or collaborative assignments will 
      be discussed in class.
      
      Special Needs. For assistance related to a physical, psychological 
      or learning disability that may impact your ability to participate fully 
      in the course, please speak with me and with Erin Salva, Coordinator of 
      Disability Services (PBX5453; salvae@kenyon.edu). 
      All information and documentation of disability is confidential. 
       
| Course Requirements and Grading Scheme: | |
| Class attendance, attitude, participation | 15% | 
| Homework, response papers (multiple deadlines) | 15% | 
| Exam I (Feb 27) | 20% | 
| Exam II (Apr 17) | 20% | 
| Writing Project (multiple deadlines) | 30% | 
| Total | 100% | 
| Date |  | Topic | Reading | Work 
          Due | |||
| Jan | 14 
         | Course Introduction: philosophy, terminology, acronyms. | Walker Introduction, pp. XIII-X | . | |||
| 16 | Video/response: Frontline: Fooling with Nature | . | Response 
          Paper 1a (in class) | ||||
| Jan | 21 | Major Classes of Contaminants; Toxicology basics | Walker Ch. 1, pp. 3-22; | . | |||
| 23 | Risk analysis and public perception. | FACSNET: 
        Reporting on Risk Assessment; Reserve reading on e-res NLM Toxicology Tutor I: Risk Assessment; Exposure Standards and Guidelines | . | ||||
| Jan | 28 | Toxicity Testing I: Dose responsiveness | Walker 
        Ch. 6, pp. 91-118; NLM Toxicology Tutor I Dose and Dose Response | . | |||
| 30 | Toxicity Testing II | Reserve reading on e-res | Response 
          Paper 2 | ||||
| Feb | 4 | Organic Pollutants: fate, transfer, bioaccumulation | Colburn Ch. 6 (pp. 87-109) 
          and Ch. 2 (pp. 23-28);  | . | |||
| 6 | Organic Pollutants: metabolism, disposition, toxicity | Walker 
        Ch. 5 (pp. 66-78); NLM Toxicology Tutor II: Toxicokinetics | Preliminary 
          Project Proposal | ||||
| Feb | 11 | Endocrinology, Receptor pharmacology | Colburn, Ch 3, 4, 5 (pp. 
          29-86) | . | |||
| 13 | Endocrine Disruptors I | Reserve reading on e-res | Response 
          Paper 3 | ||||
| Feb | 18 | Endocrine Disruptors II | Reserve reading on e-res | Response 
          Paper 4 | |||
| 20 | Dioxin-like compounds and AH Receptor | Reserve reading on e-res | Project: 
          Annotated Bibiliography | ||||
| Feb | 25 | Dioxin-like compounds | Reserve reading on e-res | Response 
          Paper 5 | |||
| 27 | EXAM I | . | . | ||||
| SPRING 
          BREAK!!! | |||||||
| Mar | 18 | Exam I post-mortem | . | ||||
| 20 | Special Topic: Smoking and Cancer | Reserve reading on e-res | Response 
          Paper 6 | ||||
| Mar | 25 | Contaminant Mixtures and Toxic Equivalents | Walker Ch. 9, pp. 153-161 | . | |||
| 27 | Abiotic factors affecting toxicity | Reserve reading on e-res | Response 
          Paper 7 | ||||
| Apr | 1 | Metals I: Toxicity, Radiation, Hormesis | Walker 
        Ch. 4, pp. 46-58. Reserve reading on e-res | Project: 
          Outline | |||
| 3 | Metals II | Reserve reading on e-res | Response 
          Paper 8 | ||||
| Apr | 8 | Population-level effects; evolution of resistance | Walker 
        Ch. 13, pp. 220-237 Reserve reading on e-res | Response 
          Paper 9 | |||
| 10 | Population-level effects II: costs of resistance | Reserve reading on e-res | Response 
          Paper 10 | ||||
| April | 15 | Remediation and prevention Issues | Reserve 
        reading on e-res Colburn et al. Ch. 12-14, pp.210-249. | . | |||
| 17 | EXAM II | . | . | ||||
| April | 22 | Social Issues/Ethics | Completed 
          Projects for Distribution | ||||
| 24 | Project Review Panels | Project for peer review | . | ||||
| Apr | 29 | Fooling with Nature Reprise | . | Response 
          Paper 1b (in class) | |||
| May | 1 | Discussion: Compare 
          Fooling with Nature Responses; | . | . | |||
| May | 7 | Revised Projects 
          Due 12:00 Noon | . | ||||