molecules to the Human
Genome Project, this course explores
the molecular basis of gene function in humans, animals,
plants, and bacteria. Topics include:
How are they built, and how do they perform all the
incredible functions of our cells?
structure and regulation. Human
genes are regulated by proteins and RNAs--encoded by yet
other genes. How does it all work? Learn how any gene
is regulated through GenBank.
Can knowledge of gene sequence and function lead to gene
surgery--replacing or repairing defective genes?
structure and function.
Mechanisms of chromosome division and segregation lead to
severe mutations. Why is mental retardation such a common
sign of hidden chromosome defects? Yet plants, particularly
agricultural crops, are often polyploid. How does polyploidy
improve crops and enable production of seedless varieties?
generation sequencing and genome-level expression
New technologies for sequencing DNA has made genome
sequencing routine. Is the $1000 genome in reach? How can
sequencing technologies enable measurements of expression of
all genes in an organism simultaneously?
an RNA world. RNAs
do more than the central dogma suggests. What newly
discovered roles do RNAs--many encoded by intergenic "junk"
DNA--play in molecular biology and human disease?