molecules to the Human
Genome Project, this course explores the molecular
basis of gene function in humans, animals, plants, and bacteria.
- Macromolecular machines.
How are they built, and how do they perform all the incredible functions
of our cells?
structure and regulation. Human genes are regulated
by proteins and RNAs--encoded by yet other genes. How does it all
work? Learn how any gene is regulated through GenBank.
Can knowledge of gene function lead to gene surgery--replacing or repairing
structure and function.
Mechanisms of chromosome division and segregation lead to severe mutations.
Why is mental retardation such a common sign of hidden chromosome
defects? Yet plants, particularly agricultural crops, are often polyploid.
How does polyploidy improve crops and enable production of seedless
- Next generation sequencing and genome-level expression analysis. New technologies for sequencing DNA has made genome sequencing routine. Is the $1000 genome in reach? How can sequencing technologies enable measurements of expression of all genes in an organism simultaneously?
- It's an RNA world. RNAs do more than the central dogma suggests. What newly discovered roles do RNAs--many encoded by intergenic "junk" DNA--play in molecular biology and human disease?