BIOL 375 Virology

Joan Slonczewski

Office: HIG 302

BIOL 375 Virology
Syllabus 2012 (in progress)

Fall 2012

Mondays 1:10-4:00, FSH 205

Resources: PLOS Pathogens; J. Virology; Virology J.

Date	#	Subject	Required Reading	Assignments
SEP	03 07	What are viruses? Rickettsia. Stanley. Iridovirus. Placenta Reading	S&F Ch. 6; Roossinck; Mimi Ch.11 (pp 393-398); Polio	News: Virus 2 questions
SEP	10 14	Poliovirus. Smithsonian; FDR and Polio; FRAP. Green Pigs. Aequorea. Pull-down assay. Brefeldin; 2010 Class; Hepatitis C Replication Wiki Virus--Progress	Belov1; Belov2 Template Page	Wiki Virus Progress
SEP	17 21	The Last Child: Polio documentary film CDC Polio strains; Neighbor-joining trees Reading	Polio Eradication; Rakoto Immunity; Ch. 23 (871-878)	2 questions
SEP	24 27	The Adaptive Immune Response. Reading	S&F Ch. 24; Holmgren Ch. 11 (pp 399-405)	Wiki Due 2 questions
OCT	01 05	Influenza 1918 documentary 1918 Reading	Lowen; Vijaykrishna, 2010 Ferret Flu	News: Flu Question
OCT	08 12	Influenza Evolution and Replication Initiation factors. HA Cleavage. eIF4F. FALL BREAK	Burgui; Zamarin
OCT	15 19	HIV evolution and AIDS NYT History Video	Kenyon hookups; Ch. 11 (405-415); Sande Ch. 2; Rambaut; Sinoussi Nobel Video	News: AIDS Individual Conferences: Paper Topic
OCT	22 26	*And the Band Played On* HIV ; discovery, transmission. NIH report. PEPFAR. Reading	Levy Ch. 2; Sinoussi NRM	2 questions
OCT NOV	29 02	HIV molecular biology. HIV Map. Euk. Reading	Sande Ch. 3; Tetherin; Bevirimat Nanotubes	2 questions
NOV	05 09	HIV host factors. Amyloid fibrils Reading	Roan; Tenofovir (Ellen) Wiki work	Start Page: Wiki paper
NOV	12 15	Dr. Ruth Greenblatt, Women's HIV Program	Short reports; Greenblatt; Seminar	Wiki Draft 1
THANKSGIVING BREAK
NOV	26 29 30	Student Readings. Comet assay. 4:10 THURSDAY SEMINAR Dr. Parris	Ch 11.5 (Herpes); Jackson; Eric Optional: HSV_Silencing
DEC	03 07	Student readings; Computer Viruses (Ron Griggs)	Computer Viruses; Irene	Paper Conferences
DEC	10	Student readings. Adenovirus receptor Lentivector Fights Cancer	Morgan; Michael	Final Wiki

INTRODUCTION. Virology, the form and function of viruses, is a field of growing importance for human and veterinary health, agriculture, and global ecology. For this advanced seminar, we select major viruses of humans and explore their means of propagation within cells, as well as their immunology and epidemiology. We consider the role of viruses in ecology, particularly global carbon cycles.

Required reading:
Sloncewski, J. L. & Foster, J. W. (2011) Microbiology: An Evolving Science (Norton, 2E) Ch. 6, 11, 23, 24.
Papers assigned on syllabus or in class.
Chapters from Levy, J. L. (2007) HIV and the Pathogenesis of AIDS (ASM Press, 3E)

Assignments.
The class meets only Monday afternoon; but each week has two due dates for work due in Moodle:
**Midnight before Monday
**Midnight before Friday
No work will be accepted after the specified date and time.

Attendance.
Because the class meets only once per week, no absence is excused. Any absence, including that due to sports or illness, must be made up by extra assignments.

MicrobeWiki Virus page. Each student authors a page using the Virus template, about an unusual or lesser known virus, preferably one infecting plants or non-human animals.

Research Paper. Topic of student's choice, in consultation with instructor. Must address a current research question. Text minimum: 2000 words (Draft 1), 3000 words (Final), in addition to figures/legends/references. Papers Index -- BIOL 375

GRADES. Your grade is based on the following:

40% Attendance and Participation. All articles need to be read and annotated for discussion in class. E-mail discussion also receives credit. 100% attendance is required, including the Nov. 29 Thursday seminar.
10% Virus short page.
20% Assignments and quizzes. Quizzes may be unannounced.
30% Research wiki paper. Grade is based half on Draft 1, half on Final Paper.

No final exam.

Standards for Projects and Exams. The standard College guidelines on individual authorship and plagiarism apply to all work, as stated in the Student Handbook 12-13. All projects, including html, must include footnotes and references cited in detail comparable to that of a term paper. Each exam must represent the work of one individual student.

Disabilities. If you have a physical, psychological, medical or learning disability that may affect your ability to carry out assigned course work, please contact the Office of Disability Services at 5453. The Coordinator of Disability Services, Erin Salva, will review your concerns and determine, with you, what accommodations are appropriate. All information and documentation of disability is confidential.