BIOL 375 Virology

Joan Slonczewski

Office: HIG 302

BIOL 375 Virology
Syllabus 2014

Fall 2014
MW 9:10-11:00, FSH 205
MW 9:10-10:00 (after Nov15)

Resources: PLOS Pathogens; J. Virology; Virology J.

Date	#	Subject	Required Reading	Assignments Due Thurs 11:59
SEP	01 03 04	What are viruses? Placenta Ebola Virus. 11:00 Panel--Ebola Virus.	S&F Ch. 6; Roossinck; Specter Wiki; Ebola1; Ebola2	Bring article 2 questions
SEP	08 10	Poliovirus. Smithsonian. The Last Child. CDC. Vaccine.	Polio overview; Wang Polio Eradicate; Circulating.	2 questions
SEP	15 17	The Immune System. Polio immunity. Adaptive Immunity.	Immunity; S&F Ch. 23 S&F Ch. 24; Holmgren	2 questions
SEP	22 24	Influenza 1918 documentary 1918; Ebola model smFISH;	Ch. 11 (Flu sec); Gao Chou; Arranz; Knepper;	2 questions
SEP OCT	29 01	Influenza Evolution and Replication Controversy. Neumann. Continued	Influenza Articles	2 questions
OCT	06 08	SARS Hepatitis B. Replication Cycle How contagious is a virus? FALL BREAK	SARS 2003; Drosten; Ge; Menachery; Hepatitis B; Vaccine; Wang; Ko; Mowa;
OCT	13 15	HIV evolution and AIDS NYT History NIH report.	Age of AIDS. Kenyon hookups; Ch. 11 (HIV section); Rambaut. Sinoussi; Sande Ch. 6, 7, 9; PEPFAR. Student Reports.	Individual Conferences: Paper Topic
OCT	20 22	HIV molecular biology and drug therapy. HIV Map. Antibody development.	Sande Ch. 3; Poropatich; Mueller. Reports. Sande Ch. 4; Doria-Rose; Apps.	1 question
OCT	27 29	HIV and tuberculosis; antiretrovirals. AIDS research lab.	Sande Ch. 26. Bhatt; Daughtridge; Andrews. Ian Perrone. Article.	Wiki work
NOV	03 05	Gene Therapy with Viruses. Animation. T-cell. CAR-T. Original. G-Quad. More G-Quad.	S&F Ch. 11, pp 450-453. The Scientist; Dupre; Aiuti. McAllister; Abou-ElEnein; Bosch.
NOV	10 12	CRISPR Defense and Gene Editing. HIV treatment. Cas9 editing. HDR. - - -	Doudna; Zebec; Patent Law; Long. Conferences (no class)	Wiki Draft 1-Template Paper Conferences Continue Wiki
NOV	17 19	Rhea Le. Dr. Kathy Gillen (9-10) Amanda He. Gillen (9-10)	Arhel. Reid.	Continue Wiki
THANKSGIVING BREAK
DEC	01 03	Sean Smith. Gillen (9-10) Alex Gonzales. Gillen (9-10)	Pancera. Prehaud.
DEC	08 19	Benji Dossetter. Gillen (9-10) - - -	Carlson.	Final Wiki

INTRODUCTION. Virology, the form and function of viruses, is a field of growing importance for human and veterinary health, agriculture, and global ecology. For this advanced seminar, we select major viruses of humans and explore their means of propagation within cells, as well as their immunology and epidemiology. We also investigate new uses of viruses for human therapy.

Required reading:
Linked to syllabus, or provided in class.

Assignments. Written assignments and proposed readings are due by Thursday 11:59pm.
No work will be accepted after the specified date and time.

Attendance.
100% attendance is expected. Any absence, including that due to sports or illness, must be made up by extra assignments.

Research Paper on MicrobeWiki. Topic of student's choice, in consultation with instructor. Must address a current research question. Text minimum: 2000 words (Draft 1), 3000 words (Final), in addition to figures/legends/references.

Papers Index -- BIOL 375

GRADES. Your grade is based on the following:

40% Attendance and Participation. All articles need to be read and annotated for discussion in class. E-mail discussion also receives credit.
30% Assignments and quizzes. Quizzes may be unannounced.
30% Research wiki paper. Grade is based half on Draft 1, half on Final Paper.

No final exam.

Standards for Projects and Exams. The standard College guidelines on individual authorship and plagiarism apply to all work, as stated in the Student Handbook 14-15. All projects, including html, must include footnotes and references cited in detail comparable to that of a term paper. Each exam must represent the work of one individual student.

Disabilities. If you have a physical, psychological, medical or learning disability that may affect your ability to carry out assigned course work, please contact the Office of Disability Services at 5453. The Coordinator of Disability Services, Erin Salva, will review your concerns and determine, with you, what accommodations are appropriate. All information and documentation of disability is confidential.