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Office: Hig 302
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Fall Semester 2003
MWF 10:10-11:00 HIG 103 |
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BIOL 363 Molecular Biology
and Genomics |
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Office: Hig 302
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Fall Semester 2003
MWF 10:10-11:00 HIG 103 |
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BIOL 363 Molecular Biology
and Genomics |
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29 |
Nucleic
acid structure. Molecules.
DNA-1. DNA Nucleic acids; DNA & RNA; Z-DNA ; HIV; Triplex |
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Quadruplex 12-mer;
22-mer. Amino Acids;
AA2
in proteins. X-Ray;
X-local;
Estrogen Receptor DNA-protein binding; Schiff Base Riff; Ras/G-protein CAP; Human ADAR1 Transcription initiation |
Parkinson
02 39-44; 232-249
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10 |
Elongation;
RnaPol-Bact;
RnaPol-Euk
Eukaryotic RNA Polymerase RNA Interference. Ambion; |
MB
152-171; 262-280; Gnatt 01 Artsimovitch 01 |
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17 |
-- No Class -- (replaced
by 9/11 seminar) Bacterial Gene Regulation. CAP-CTD ; Benoff Competitive binding; Allostery TEST 1 |
TEST 1 (class) |
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24 26 |
Euk. General TFs. DAB
PolII; Zn-finger |
MB
297-321 |
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| OCT |
1 3 |
Translation initiation.
Initiation. PDB Ribosome 30S structure. Model. Periodic Table Ribosome function |
MB
529-545;
607-616 |
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6 |
70S;
Elongation; Ribosome
"Protein Jive Sutra" Translation in the Nucleus? Notes OCTOBER BREAK |
MB
571-593 Iborra 01 |
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13
15 |
RNA
Splicing; Lupus;
Spliceosome;
SF3b Movie |
MB
419-439; Golas
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PDB Proposal |
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20
22 24 |
Di-Ubi;
Tetra-Ubi; Research;
Parkinson's disease |
Proteasome;
Conaway 02 Micro RNA paper |
TEST
2 DUE |
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29 31 |
DNA Replication;
Beta
ring |
DNA
Rep; MB 654-668 MB 668-679; |
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3
5 |
Homologous Recombination;
RuvA Transposable Elements Genomics: An Overview. Human Genome; Microarray |
MB
718-740 |
Individual
Web project consultations |
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12 14 |
Post-Genomics. Aptamers;
example; SELEX; |
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19 21 |
Proteomics;
PQS; a-hemol;
BRCA/DNA; MIPS |
Sali 03 Hannash 03 Chime project |
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| # | # | NOVEMBER BREAK | # | # |
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3 5 |
Human
Cloning. Cibelli. Make
a baby. Fertilization Epigenetics. Embryonic Stem Cell Library. Transgenic mice: Tilghman video. H19-Igf2; H19; Igf2; Beckman-Wiedeman |
Cibelli 02 (SciAm) |
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| Dec. | 8 12 |
Methylation; Cancer & Imprinting Student projects Student projects & course evaluation |
H19-Igf2 2003 |
Web Due |
| Dec. |
16 |
Web Tutorial Finished 4:30PM. No broken links. |
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| INTRODUCTION. The molecular
and genomic basis of life is at the heart of biology today. How do molecular
machines build organisms, based on the blueprint of the genome? How
are genomes shaped by the function of genomes? We will learn the techniques
and explore research questions at the forefront of molecular research.
Web resources will be used in class, and for your assignments. Required reading. Tests. There are three tests, two of them take-home. The Chime Molecular Tutorial Project substitutes for the final exam. Final Projects. A Chime Tutorial is required. It is recommended that two partners share a project, especially if you have not previously used Chime. Examples of past projects may be viewed at Biomolecules at Kenyon.
Standards for Projects and Exams. The standard College guidelines on individual authorship and plagiarism apply to all work, as stated in the Student Handbook 03-04. All projects, including html, must include footnotes and references cited in detail comparable to that of a term paper. Each exam must represent the work of one individual student. Disabilities. If you have a physical, psychological, medical or learning disability that may affect your ability to carry out assigned course work, please contact the Office of Disability Services at 5453. The Coordinator of Disability Services, Erin Salva, will review your concerns and determine, with you, what accommodations are appropriate. All information and documentation of disability is confidential. Home
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