Slonczewski
Biology Dept
Kenyon College
Bacterial pH Research Lab
funded by the  National Science Foundation
Lab Links
How to Run 2-D Gels

Jessie Wilks '08, Dan Tate '06,
Geetha Kannan '07, Joan Slonczewski
Piero Sanfilippo '09, Jessie Wilks '08


Everett Hayes '04 and Liz Yohannes grow cells for microarray hybridization studies of
pH-dependent gene expression. Arrays funded by our HHMI award, in collaboration
with Sandra BonDurant at the UW-Madison Gene Expression Center.
Summer of 2004.

How does Escherichia coli survive in extreme acid or base?  Genes for these traits enable E. coli to survive passage through the stomach and grow in the intestine.  Most E. coli strains enhance human digestion, but a few cause sudden illness, even death.  The Bacterial pH Research Lab identifies genes and proteins regulated by acid and base, which may be targets to design new antibiotics.
Current Research:
  • Extreme pH: "The Movie"
  • Cell Signalling Proteins in E. coli
  • Life in the upper intestine



    • Escherichia coli grows on the surface of human cells.  Scanning electron micrograph from UMB.

    2-D gel images analyzed by Kenyon students using Compugen:  OppA protein is induced in pta-ack (acetate kinase mutant).

    Alumni from the Bacterial pH Research Lab

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