| BIOL
114 Genetics and Development |
|
| UNDER CONSTRUCTION! Last
modified 1/02/2009 MWF 8:10- 9:00 a.m. (Period 1)
M,
W, F 7:30- 8:00, 9- 11:30 a.m. Linked articles: Only viewed at Kenyon. This course introduces the mechanisms of heredity, the expression of genetic information, and the genetic control of development. Special emphasis is placed on genetic and biochemical approaches toward delineating fundamental cellular and developmental processes.
How to do well in this class:
How
to contact the instructor: Office hours, the weekly review session, and e-mail
are the best ways to make contact with me. Also, you may call me at home before
9:00 p.m.
NOTE ON EXAMS AND QUIZZES: Exams or quizzes missed due to unexcused absences (e.g. my alarm didn't go off) will count as a zero. Exams missed due to an excused absence can be made up. It is the responsibility of the student to make arrangements to do so with the instructor. When an exam conflicts with a scheduled excusable event, the student must contact the instructor one week before the exam is scheduled to arrange for an alternate time. Ordinarily, this will be before the rest of the class takes the exam. Therefore, athletes should check the syllabus and their athletic contest schedules closely and make note of any conflicts. There will be no make up quizzes. If you miss a quiz due to an excused absence, it will not count as a zero and the two lowest grades of the remaining quizzes will be dropped.
Academic Honesty. Do not lie, cheat, or plagiarize. This class will follow the official Kenyon College position on academic honesty. It is your responsibility to review and observe the official College policy on academic honesty. Special Needs. College policy provides for reasonable accomodations for documented physical, psychological or learning disabilities that may impact your ability to participate fully in the course. Please speak with me and with Erin Salva, Coordinator of Disability Services (PBX 5453; salvae@kenyon.edu). All information and documentation of disability is confidential. Please see the Disability Services web site for more information. Logistical details of any approved accomodation (e.g. extended exam time) must be arranged with the instructor in advance. |
If particular pages or a section number follow a chapter you are responsible for
just those pages or sections.
| DATE | TOPIC & WEBNOTES links | READING second edition-- Color coded | Reading third edition |
|
Jan 12 M
|
The Central Dogma Ch. 15 (section 15.3, pp. 334-336) |
The Central Dogma Ch. 15 (pp. 320-322). | |
|
Jan 14 W |
DNA
structure(optional), Chromosomes |
Ch. 4 (4.1, 4.2); pg. 130; essay pg. 87 |
Ch. 4 (4.1, 4.2); pg. 120-121; Box 4.1 pg. 75 pg 124 (the nucleus) |
| Jan 16 F | histone code: Gel electrophoresis | Ch. 18 (18.2), Box 4.1 pg. 78, box 19.2 pg. 412 | Ch. 18 (18.2), Bioskills 7 pg B12-B13, box 19.1 pg. 398 |
| Jan 19 M | DNA
as the genetic material; centrifugation transformation, conjugation, transduction |
Ch. 14 (303-310), Box 7.1 pg. 140, Box 19.1 pg. 404 |
Ch. 14 (295-302), Box 7.1 pg. 133, Box 12.2 pg. 256 |
| Jan 21 W | DNA replication, telomeres |
Ch. 14 pp. 310-318 tissue engineering paper |
Ch. 14 (sections 3 and 4) tissue engineering paper |
| Jan 23 F |
Mitosis |
Ch. 11 pg. 227, sections 11.1, 11.2 | Ch. 11 pg. 222, sections 11.1 and 11.2 |
|
Jan 26 M
|
Meiosis animation
optional
karyotyping link
|
Ch. 12 (all except section 12.3), Fig 25.9 pg. 547 |
Ch. 12 (all except section 12.3), Fig 26.8 pg. 535 |
| Jan 28 W | Mendelian inheritance
|
Ch. 13 pp. 269-281; Dihybrid Cross | Ch. 13 pp. 265-276; Bioskills 9 Dihybrid Cross |
| Jan. 30 F | Sex
linked traits, recombination |
Ch. 13 pp 281-286; Linkage More Practice | Ch. 13 pp 276-281; Linkage More Practice |
| Feb 2 M | Gene mapping, pedigrees | Ch. 13 (sec. 13.6), Ch. 19 (sec. 19.3) | Ch. 13 (sec. 13.6), Ch. 19 (sec. 19.4) |
| Feb 4 W | Exam
1
May bring 8.5 x 11 one-sided "cheat sheet". |
||
|
Feb 6 F
|
Ch. 13 (sec. 13.5) Download Flowers(optional)
|
Ch. 13 (sec. 13.5) Download Flowers(optional) | |
|
Feb 9 M |
Chapter 15, Box 27.1 pg 588
Beadle and Tatum animation- click on test tubes |
Chapter 15, Box 28.1 pg 576 Beadle and Tatum animation- click on test tubes |
|
|
Feb 11 W
|
Ch. 4 (sec. 4.3); Ch 16 pp. 338-341
|
Ch. 4 (sec. 4.3); Ch 16 pp. 329 and section 16.1 | |
| Feb 13 F |
Eukaryotic
transcription and splicing |
Ch. 16 (section 16.2); pg. 438-439 (gene # and alternate splicing) Nobel Prize for split genes |
Ch. 16 (section 16.2); pg. 426-427 (Why do humans have so few
genes?) Nobel Prize for split genes |
| Feb 16 | Translation | Ch. 16 (sections 16.3, .4, .5) Essay on antiobiotics pg.358-9 | Ch. 16 (sections 16.3, .4, .5) |
|
Feb 18
|
DNA mutation
and repair
|
Ch. 14 (sec. 14.5, 14.6); Ch. 16 (sec. 16.6); essay pg. 535
|
Ch. 14 (sec. 14.5); Ch. 16 pp. (sec. 16.6) |
| Feb 20 |
Applying Central Dogma Concepts I: Regulation of the eukaryotic cell cycle. |
Ch. 11(sec. 11.3,11.4)Cell
cycle game -optional |
Ch. 11(sec. 11.3,11.4)Cell cycle game -optional |
|
Feb 23 m
|
Ch. 18 (18.6); Smoking
and Lung Cancer essay pg. 322
|
Ch. 18 (18.6); Smoking and Lung Cancer | |
| Feb 25 w | Applying Central Dogma Concepts II: Immune System and antibody production | Ch. 49 (sec 49.2) | Ch. 49 (sec 49.2) |
| Feb 27 f | EXAM 2 Bring code with notes on back | ------- | |
|
Mar
2-13
|
SPRING
BREAK
|
No
Class Meetings
|
No Class Meetings |
|
Mar 16 m |
Ch. 19 (intro, sec. 19.1, .2)
Plasmid (downloaded with Flowers) Techniques page if you're interested (for PCR animation click on techniques, amplifying, PCR). |
Ch. 19 (intro, sec. 19.1, .2, .3) Plasmid (downloaded with Flowers) Techniques page if you're interested (for PCR animation click on techniques, amplifying, PCR). |
|
| Mar 18 w |
Approaches II: DNA
sequencing PCR |
Ch. 20 (Pg. 427, recent
technological advances, fig. 20.1) |
Summary Table, pg. 406-407. |
| Mar 20 f |
Ch. 17 (Intro, sections .1, .2 and .3) |
Ch. 17 (Intro, sections .1, .2 and .3) | |
|
Mar 23 m
|
Ch. 17 (section 17.4) operon
practice
|
Ch. 17 (section 17.4) operon practice | |
| Mar 25 w |
DNA binding proteins |
Ch. 17 (section 17.5) footprinting animation |
Ch. 17 (section 17.5) footprinting animation |
| Mar 27 f |
Ch. 18 (pp. 382-383, 18.3, 18.4) |
Ch. 18 (pp. 370-371, 18.3, 18.4) |
|
|
Mar 30 m
|
Ch. 18 (18.5)
|
Ch. 18 (18.5)
|
|
| Apr 1 w | Problems and Approaches III: Measuring Gene Expression: Northern blots, RT-PCR, cDNA microarrays; Western blots | Box
19.2 pp. 412-413; Ch. 20 pp. 440 DNA microarrays DNA Chip (optional) |
Box
19.1 pp. 398-399; Ch. 20 pp. 428-429 DNA microarrays DNA Chip (optional) |
| Apr 3 f | Special topic: RNAi animation and RNAi Nobel | RNAi and riboswitches: Gibbs (2003) Scientific
American article (local access only) |
RNAi and riboswitches: Gibbs (2003) Scientific
American article (local access only) |
| Apr 6 m | gene therapy | Chap 19 (sec. 19.4) zinc
finger nuclease article on moodle knock out mice (optional) |
Chap 19 (sec. 19.5) zinc
finger nuclease article on moodle knock out mice (optional) |
|
Apr 8 w
|
EXAM 3 may bring 8.5 x 11 one sided cheat sheet | May start exam at 8:00 a.m. | May start exam at 8:00 a.m. |
| Apr 10 f |
Overview
of Developmental Processes; Model
organisms (click on techniques, then model organisms)
|
Ch. 21(pp. 446-447); Ch. 22 ( pp. 469-470, sec. 22.3) pg 757
box 33.1, pg. 725 box 32.1
|
|
| Apr 13 m | Fertilization and Cleavage in animals | Ch. 21(pp. 447- 458) | |
| Apr 15 w |
Cell
Movement and Gastrulation (optional) |
Ch. 21 (pp. 458-461) Gastrulation movies(optional) | |
|
Apr 17 f |
Pattern formation in Animals |
Ch. 21 (pp. 463-466); Ch 22 (sec. 22.1) |
|
|
Apr 20 m
|
Ch. 26 (sec. 26.3); Box 22.2 (pg. 482) , Twinned genes | ||
| Apr 22 w |
Ch. 22 (section 22.4), Ch 8 pp 166-168
miRNAs in myogenesis (optional) |
||
| Apr 24 f | Plant
embryogenesis; Pattern Formation in Plants: Arabidopsis flowering |
Ch. 21 pp. (462-463); Ch. 22 (sec. 22.2) Box 29.1 pg. 643. Skim ch 40 (section 40.2 - end). | |
|
Apr 27 m
|
Apoptosis C. elegans | Box 22.4 pg. 486 and animation | |
| Apr 29 w |
Essay
pg. 466, Box 22.3 pg. 484, essay pg.489
|
||
| May 1 | Make up or special topic | ------------ | |
| May 4 Monday | Exam 4 at 6:30 p.m. | Exam 4 in TOM 101 | |