Biology Dept
Kenyon College
KAP   Genetics and Development
Fall Section Spring Section 1 Spring Section 2
Fall Semester 2004
Last modified 11/19/04
Latest update overrides all previous versions (electronic and print).

MWF 11:10 AM-12:00 Noon (Period 4)
Tomsich Hall Room 101
(Owen York Lecture Hall)

Dr. Wade Powell

FSH 202, x5396

Office hours:
Mondays 3-5 PM; Tuesdays 3-4 PM; Thursdays 9-11 AM
(and by appointment)

Visitors: Please report corrections to course directors.

Linked articles: Only viewed at Kenyon.
This course introduces the mechanisms of heredity, the expression of genetic information, and the genetic control of development. Genetics and development are part of a continuous process revealing a fundamental kinship of life on earth.
Required Reading--color coded in Syllabus
Biological Science, by Scott Freeman, 2002
Biological Science CD, by Scott Freeman, 2002
Articles and problemslinked to webnotes, or handed out in class.

Genetics programs: Download herePermission to distribute from D. K. Schmidel.

  Flowers, Mendelian inheritance of traits

  Plasmid, restriction mapping of a recombinant plasmid
Further reading (optional)
Cartoon Guide to Genetics, by Gonick and Wheelis.

How to do well in this course.
  • Attend EVERY class.
  • Complete all assigned reading by the date assigned on the syllabus, i.e. before class.
  • Participate actively in class discussion. Your silence tells me that your understanding of the topic is complete, and I am moving too slowly through the material. Your questions direct me to revisit difficult concepts. Your insightful comments demonstrate hard work and commitment to learning biology.
  • For additional practice, do the problems and tutorials (found in web notes, at end of textbook chapters, and on the textbook CD) promptly.  These are good preparation for the in-class or take-home quizzes that happen most Fridays.
  • Attend review sessions held before tests. These optional sessions offer you another chance to ask your own questions and review difficult topics.
  • Review your chemistry. This course presumes a thorough knowledge of at least high school-level chemistry. Get comfortable with electrons, hydrogen bonds, and the important functional groups.
  • Stay in contact with your instructor. I read e-mail several times daily. I also have plenty of office hours; please stop by.
Class resources. Web Notes include lecture outline and linked articles. Slides and animations are on the Web.

Grades.  Grades are based on:

  • 20% each of four one-hour Exams
  • 20% on ten (10) Weekly Quizzes. [NOTE: Make-up quizzes will not be possible. Please don't ask. To compensate for conflicts due to athletics, performances, illnesses, busy schedules, etc., you may skip up to two quizzes without penalty or prior permission. Only the eight (8) highest quiz scores count toward the quiz average.
  • A two-hour final exam is OPTIONAL, to substitute for your lowest single exam grade of the semester. The final exam cannot substitute for the quiz average.

Academic Honesty.  This class will follow the official Kenyon College position on academic honesty. It is your responsibility to review the official College policy on academic honesty and adhere to this policy.

Special Needs. For assistance related to a physical, psychological or learning disability that may impact your ability to participate fully in the course, please speak with the instructor and with Erin Salva, Coordinator of Disability Services (PBX 5453; salvae@kenyon.edu). All information and documentation of disability is confidential. Please see the Disability Services web site for more information.


DATE TOPIC & WEBNOTES links READING -- Color coded
Aug 30
Course introduction; history of genetics; genes and genomes.
Environment; Primates
Sept. 1 DNA structure Ch. 3 pp. 47-48 and 59-62; errors in text; Classic papers
Sept. 3 DNA replication; PCR; DNA sequencing; QUIZ 1 Ch. 12 pp. 232-244, Activities 12.1, 12.2

Sept. 6

Chromosome structure

Ch. 15 p. 298-299 (Fig. 15.3)

Sept. 8 Meiosis Ch. 8 pp. 155-164; Ch. 9 pp. 176-193; Activities 8.2, 9.1
Sept. 10

Mendelian inheritance

Ch. 10 pp. 194-205; Activities 10.1, 10.2. Dihybrid Cross;
Download Flowers
Sept. 13
Sex linkage and pedigree analysis

Ch. 10 pp. 206-207;Ch. 17 pp. 339-341; X and Y

Sept. 15
Recombination and gene mapping Ch. 10 pp 207-209; Linkage
Sept. 17 Gene product interactions; non-Mendelian genetics QUIZ 3 Ch. 10 pp. 209-214
Sept. 20 Genetics Catch-up More practice problems
Sept. 22 EXAM 1 (score distribution) ---------- 
Sept. 24
How Genes Work I:  DNA as the genetic material
Ch. 11, pp. 217-220

Sept. 27

How Genes Work II:  One Gene, One Enzyme; m RNA synthesis
Ch. 11, pp. 220-223; Ch. 13 252-256; Activity 13.1; Activity 11.1
Sept. 29
Genetic Code
Ch. 11, pp. 223-227; Activity 11.2
Oct. 1 Translation. QUIZ 4 Ch. 13, pp. 259-270; Activity 13.2
Oct. 4 Eukaryotic transcription and splicing Ch. 13, pp. 256-259
Oct. 6
DNA mutation and repair
Ch. 12, pp. 243-249; RNA Editing
Oct. 8

Applying Central Dogma Concepts I:  Regulation of the eukaryotic cell cycle. QUIZ 5

Ch. 8, pp. 155-159 and 164-173; Activity 8.1;
Oct. 11

NO CLASS: October Reading Days

Oct. 13
Cell cycle and cancer Smoking and Lung Cancer
Oct. 15
Applying Central Dogma Concepts II: Immune System and antibody production
Ch. 46, pp. 891-911
Oct. 18 EXAM 2 (score distribution) -------
Oct. 20
Problems and Approaches I:
1. PCR: Making lots of DNA from just a little.and DNA 2. How to determine the sequence of a DNA molecule
Ch. 12 pp. 240-243, Activities 12.1, 12.2
Oct. 22 Problems and Approaches II: Measuring Gene Expression: northern blots, RT-PCR, western blots, cDNA microarrays. Ch. 15 pp. 308-309; Ch. 16 pp. 320-330; DNA Chip
Oct. 25 Problems and Approaches III: Customizing DNA molecules. Recombinant DNA, transgenic organisms, and gene therapy Ch. 3, pg. 50; Ch. 15, pp. 308-309; Ch. 17 pp. 339 - 345;Ch. 15, pg. 302; Ch. 17 pp. 335-339 & 345 - 351; Activity 17.1; Plasmid (downloaded with Flowers)
Oct. 27
Prokaryotic Gene Expression I:  Operons
Two take-home quizzes are due Monday November 1. Download here: QUIZ 6 & QUIZ 7.

Ch. 14, pp. 274-295

Oct. 29

Prokaryotic Gene Expression II:  Operon Analysis; Regulons, Promoters

Ch. 14, pp. 274-295; Activity 14.1

Nov. 1

Eukaryotic Gene Expression I:  Transcriptional Activation.

Ch. 15 pp. 296-305

Nov. 3
Eukaryotic Gene Expression II:  Classes and functions of transcription factors; Analysis of regulatory motifs
Ch. 15 pp. 305--307
Nov. 5 Eukaryotic Gene Expression III:  Nucleosomes and
transcription; post-transcriptional regulation
Ch. 15 pp. 298-300; Activity 15.1
Nov. 8 Junk DNA? non-coding RNAs and gene expression RNAi and riboswitches: Gibbs (2003) Scientific American article (local access only)
RNAi article from The Scientist
Nov. 10 EXAM 3 (score distribution) ----------------------------
Nov. 12
Overview of Developmental Processes;
Gene Expression and Development
Ch. 18 pp. 354-360; Activity 18.1
Ch. 18 pp. 361-368; Signals
Nov. 15 Microbial development and more microbial development; Heterocysts
Nov. 17
Pattern Formation in Plants: Arabidopsis flowering;
Ch. 18, pp. 355-356; Ch. 19, pp. 379-380; Ch. 20 pp. 399-402
Nov. 19 Fertilization and Cleavage in animals; QUIZ 9 Ch. 19, pp. 370-382 
Nov. 29 Cell Movement and Gastrulation.

Ch. 19 pp. 382-389; Activity 19.1

Dec. 1

Organizing the embryo;
Ch. 19 pp. 383-389
Dec. 3
Pattern formation in Animals; QUIZ 10
Ch. 20 pp. 391-399; Activity 20.1; Animated tutorial
Dec. 6 Hox Genes; Gene/Genome Duplication and Molecular Evolution Ch. 20 pp. 396-399; Ch. 24 pp. 473-476. C. elegans, Twinned genes
Dec. 8 Cell Differentiation: Neurulation and organogenesis. Ch. 20 pp. 402-409
Dec. 10
Special Topic: Embryonic Stem Cells and Human Cloning Ch. 20 pp. 406-407
Dec. 13 EXAM 4 ------------