Biology Dept
Kenyon College
KAP   Genetics and Development
Fall Section Spring Section 1 Spring Section 2

Spring Semester 2004
Web syllabus last updated 05/03/04
This update overrides all previous versions.

MWF 10:10-11:00 AM (Period 3)
101 Tomsich Hall

Dr. Wade Powell

FSH 202, x5396

Office hours:
Mondays: 3-5
Tuesdays: 3-4
Wednesdays: 11-1

Visitors: Please report corrections to course directors.

Linked articles: Only viewed at Kenyon.
This course introduces the mechanisms of heredity, the expression of genetic information, and the genetic control of development. Special emphasis is placed on genetic and biochemical approaches toward delineating fundamental cellular and developmental processes.
Class Resources and Required Reading--color coded in Syllabus

Textbook: Biological Science, by Scott Freeman, 2002
Text CD Supplement: Biological Science CD, by Scott Freeman, 2002
WebnotesArticles and problems linked to webnotes, or handed out in class.

Genetics programs: Download herePermission to distribute fromD. K. Schmidel.

  Flowers, Mendelian inheritance of traits

  Plasmid, restriction mapping of a recombinant plasmid

Further reading (optional): Cartoon Guide to Genetics, by Gonick and Wheelis.

How to do well in this course.
  • Attend EVERY class.
  • Be prepared: Complete all assigned reading by the date assigned on the syllabus (i.e. before class).
  • Participate actively in class discussion. Your silence tells me that your understanding of the topic is complete, and I am moving too slowly through the material. Your questions direct me to revisit difficult concepts. Your insightful comments demonstrate hard work and commitment to learning biology. Thorough preparation and class participation are viewed very favorably in determination of final grades.
  • For additional practice, do the problems and tutorials (found in web notes, text, and text CD) promptly.  These are good preparation for the in-class or take-home quizzes that happen most Fridays.
  • Attend weekly reviews. Optional Q&A sessions are held Thursdays at 11:10 AM (Common Hour) in FSH 103.
  • Attend review sessions held before tests. These optional sessions offer you another chance to ask your own questions and review difficult topics.
  • Review your chemistry. This course presumes a thorough knowledge of at least high school-level chemistry. Get comfortable with electrons, hydrogen bonds, and the important functional groups.
  • Stay in contact with your instructor. I read e-mail several times daily. I also have plenty of office hours; please stop by.

Grades.  Grades are based on:

  • 20% each of four one-hour Exams
  • 20% on ten (10) Friday Quizzes. Please note: Make-up quizzes will not be possible. The eight (8) highest quiz scores count toward the quiz average; drop your two (2) lowest. The dropped quizzes are intended to compensate for conflicts due to illnesses, athletics, performances, etc.
  • A two-hour, comprehensive final exam is OPTIONAL, to substitute for your lowest single exam grade of the semester. The final exam cannot substitute for the quiz average.

Academic Honesty.  Do not lie, cheat, or plagiarize. This class will follow the official Kenyon College position on academic honesty. It is your responsibility to review and observe the official College policy on academic honesty (see Kenyon College 2003-04 Course of Study, pp. 26 - 29).

Special Needs. College policy provides for reasonable accomodations for documented physical, psychological or learning disabilities that may impact your ability to participate fully in the course. Please speak with me and with Erin Salva, Coordinator of Disability Services (PBX 5453; salvae@kenyon.edu). All information and documentation of disability is confidential. Please see the Disability Services web site for more information.


DATE TOPIC & WEBNOTES links READING -- Color coded
Jan 19
Course introduction; history of genetics; genes and genomes.
Environment; Primates

Jan 21

Chromosome structure

Ch. 15 p. 298-299 (Fig. 15.3)

Jan 23 Mitosis and meiosis; QUIZ 1 Ch. 8 pp. 155-164; Ch. 9 pp. 176-193; Activities 8.2, 9.1
Jan 26 DNA structure Ch. 3 pp. 47-48 and 59-62; errors in text; Classic papers
Jan 28 DNA replication; PCR; DNA sequencing Ch. 12 pp. 232-244, Activities 12.1, 12.2
Jan 30

Mendelian inheritance

Ch. 10 pp. 194-205; Activities 10.1, 10.2. Dihybrid Cross; Download Flowers
Feb 2
Sex linkage and pedigree analysis

Ch. 10 pp. 206-207;Ch. 17 pp. 339-341; X and Y

Feb 4 Recombination and mapping Ch. 10 pp 207-209; Linkage
Feb 6 Gene product interactions; non-Mendelian genetics QUIZ 3 Ch. 10 pp. 209-214
Feb 9 Catch-up More practice problems
Feb 11 EXAM 1 (score distribution) -------
Feb 13
How Genes Work I:  DNA as the genetic material
Ch. 11, pp. 217-220

Feb 16

How Genes Work II:  One Gene, One Enzyme; m RNA synthesis
Ch. 11, pp. 220-223; Ch. 13 252-256; Activity 13.1; Activity 11.1
Feb 18
Genetic Code
Ch. 11, pp. 223-227; Activity 11.2
Feb 20 Translation. QUIZ 4 Ch. 13, pp. 259-270; Activity 13.2
Feb 23 Eukaryotic transcription and splicing Ch. 13, pp. 256-259
Feb 25
DNA mutation and repair
Ch. 12, pp. 243-249; RNA Editing
Feb 27

Applying Central Dogma Concepts I:  Cell cycle and cancer. QUIZ 5

Ch. 8, pp. 155-159 and 164-173; Activity 8.1; Smoking and Lung Cancer
Mar 1
Applying Central Dogma Concepts II: Immune System and antibody production
Ch. 46, pp. 891-911
Mar 3 Catch-up -------
Mar 5 EXAM 2 -------
Mar 6-21
No Class Meetings

Mar 22-24
(Note: class by Dr.Slonczewski)

Handy Techniques: Electrophoresis, Restriction Endonucleases, and Southern Blots

Recombinant DNA, transgenic organisms, and gene therapy

Measuring Gene Expression: Northerns, Westerns, and microarrays
Ch. 3, pg. 50; Ch. 15, pp. 308-309; Ch. 17 pp. 339 - 345

Ch. 15, pg. 302; Ch. 17 pp. 335-339; 345 - 351; Activity 17.1; Plasmid (downloaded with Flowers)

DNA Chip Ch. 15 pp. 308-309; Ch. 16 pp. 320-330
Mar 24 (Note: class by Dr.Slonczewski)

Handy techniques, continued.


Mar 26 (Powell returns)

Handy Techniques III: PCR, RT-PCR, and DNA Sequencing; QUIZ 6 (take-home; due Monday March 29)

Ch. 12 pp. 240-244

Mar 29
Prokaryotic Gene Expression I:  Operons
Ch. 14, pp. 274-295
Mar 31

Prokaryotic Gene Expression II:  Operon Analysis; Regulons, Promoters

Ch. 14, pp. 274-295; Activity 14.1

Apr 2

Eukaryotic Gene Expression I:  Transcriptional Activation. QUIZ 7

Ch. 15 pp. 296-305

Apr 5
Eukaryotic Gene Expression II:  Classes and functions of transcription factors; Analysis of regulatory motifs
Ch. 15 pp. 305--307
Apr 7 Eukaryotic Gene Expression III:  Nucleosomes and
transcription; post-transcriptional regulation
Ch. 15 pp. 298-300; Activity 15.1
Apr 9 Catch-up ----------
Apr 12 EXAM 3 ----------
Apr 14
Overview of Developmental Processes; Gene Expression and Development
Ch. 18 pp. 354-360; Activity 18.1; Ch. 18 pp. 361-368; Signals
Apr 16 Microbial development and more microbial development; QUIZ 8 Heterocysts
Apr 19 Fertilization and Cleavage in animals Ch. 19, pp. 370-382
Apr 21 Cell Movement and Gastrulation.

Ch. 19 pp. 382-389; Activity 19.1

Apr 23

Organizing the embryo; QUIZ 9
Ch. 19 pp. 383-389
Apr 26
Pattern formation in Animals
Ch. 20 pp. 391-399; Activity 20.1; Animated tutorial
Apr 28 Gene Duplication and Molecular Evolution: Hox Genes Ch. 20 pp. 396-399; Ch. 24 pp. 473-476. C. elegans, Twinned genes
Apr 30 Cell Differentiation: Neurulation and organogenesis. QUIZ 10 Ch. 20 pp. 402-409
May 3
Pattern Formation in Plants: Arabidopsis flowering
Plant embryogenesis; meristems
Ch. 18, pp. 355-356; Ch. 19, pp. 379-380; Ch. 20 pp. 399-402
May 5 Catch-up; Review; Course Evaluation ------------
May 7 EXAM 4 ------------