KAP Genetics and Development
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Spring Semester 2004 MWF 10:10-11:00
AM (Period 3) Dr. Wade Powell FSH 202, x5396 powellw@kenyon.edu Office hours: Mondays: 3-5 Tuesdays: 3-4 Wednesdays: 11-1 Visitors: Please report corrections to course directors. Linked articles: Only viewed at Kenyon. This course introduces the mechanisms of heredity, the expression of genetic information, and the genetic control of development. Special emphasis is placed on genetic and biochemical approaches toward delineating fundamental cellular and developmental processes.
How to do well in this course.
Grades. Grades are based on:
Academic Honesty. Do not lie, cheat, or plagiarize. This class will follow the official Kenyon College position on academic honesty. It is your responsibility to review and observe the official College policy on academic honesty (see Kenyon College 2003-04 Course of Study, pp. 26 - 29). Special Needs. College policy provides for reasonable accomodations for documented physical, psychological or learning disabilities that may impact your ability to participate fully in the course. Please speak with me and with Erin Salva, Coordinator of Disability Services (PBX 5453; salvae@kenyon.edu). All information and documentation of disability is confidential. Please see the Disability Services web site for more information. |
DATE | TOPIC & WEBNOTES links | READING -- Color coded |
Jan 19
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Course
introduction; history
of genetics; genes and genomes.
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Jan 21 |
Ch. 15 p. 298-299 (Fig. 15.3) |
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Jan 23 | Mitosis and meiosis; QUIZ 1 | Ch. 8 pp. 155-164; Ch. 9 pp. 176-193; Activities 8.2, 9.1 |
Jan 26 | DNA structure | Ch. 3 pp. 47-48 and 59-62; errors in text; Classic papers |
Jan 28 | DNA replication; PCR; DNA sequencing | Ch. 12 pp. 232-244, Activities 12.1, 12.2 |
Jan 30 |
Mendelian inheritance |
Ch. 10 pp. 194-205; Activities 10.1, 10.2. Dihybrid Cross; Download Flowers |
Feb 2
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Ch. 10 pp. 206-207;Ch. 17 pp. 339-341; X and Y |
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Feb 4 | Recombination and mapping | Ch. 10 pp 207-209; Linkage |
Feb 6 | Gene product interactions; non-Mendelian genetics QUIZ 3 | Ch. 10 pp. 209-214 |
Feb 9 | Catch-up | More practice problems |
Feb 11 | EXAM 1 (score distribution) | ------- |
Feb 13
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Ch. 11, pp. 217-220
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Feb 16 |
Ch. 11, pp. 220-223;
Ch. 13 252-256; Activity 13.1;
Activity 11.1
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Feb 18
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Ch. 11, pp. 223-227; Activity
11.2
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Feb 20 | Translation. QUIZ 4 | Ch. 13, pp. 259-270; Activity 13.2 |
Feb 23 | Eukaryotic transcription and splicing | Ch. 13, pp. 256-259 |
Feb
25
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Ch. 12, pp. 243-249; RNA
Editing
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Feb 27 |
Applying Central Dogma Concepts I: Cell cycle and cancer. QUIZ 5 |
Ch. 8, pp. 155-159 and 164-173; Activity 8.1; Smoking and Lung Cancer |
Mar
1
|
Ch. 46, pp. 891-911
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Mar 3 | Catch-up | ------- |
Mar 5 | EXAM 2 | ------- |
Mar 6-21
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SPRING BREAK
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No Class Meetings
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Mar 22-24 |
Handy
Techniques: Electrophoresis,
Restriction
Endonucleases, and Southern
Blots
Recombinant DNA, transgenic organisms, and gene therapy Measuring Gene Expression: Northerns, Westerns, and microarrays |
Ch. 3, pg. 50; Ch. 15, pp.
308-309; Ch. 17 pp. 339 - 345
Ch. 15, pg. 302; Ch. 17 pp. 335-339; 345 - 351; Activity 17.1; Plasmid (downloaded with Flowers) DNA Chip Ch. 15 pp. 308-309; Ch. 16 pp. 320-330 |
Mar 24 (Note: class by Dr.Slonczewski) |
Handy techniques, continued. |
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Mar 26 (Powell returns) |
Handy Techniques III: PCR, RT-PCR, and DNA Sequencing; QUIZ 6 (take-home; due Monday March 29) |
Ch. 12 pp. 240-244 |
Mar 29
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Ch. 14, pp. 274-295
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Mar 31 |
Prokaryotic Gene Expression II: Operon Analysis; Regulons, Promoters |
Ch. 14, pp. 274-295; Activity 14.1 |
Apr 2 |
Eukaryotic Gene Expression I: Transcriptional Activation. QUIZ 7 |
Ch. 15 pp. 296-305 |
Apr
5
|
Ch. 15 pp. 305--307
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Apr 7 | Eukaryotic
Gene Expression III: Nucleosomes and transcription; post-transcriptional regulation |
Ch. 15 pp. 298-300; Activity 15.1 |
Apr 9 | Catch-up | ---------- |
Apr 12 | EXAM 3 | ---------- |
Apr 14
|
Ch. 18 pp. 354-360; Activity 18.1; Ch. 18
pp. 361-368; Signals
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Apr 16 | Microbial development and more microbial development; QUIZ 8 | Heterocysts |
Apr 19 | Fertilization and Cleavage in animals | Ch. 19, pp. 370-382 |
Apr 21 | Cell Movement and Gastrulation. |
Ch. 19 pp. 382-389; Activity 19.1 |
Apr 23 |
Organizing
the embryo; QUIZ 9
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Ch. 19 pp. 383-389 |
Apr 26
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Ch. 20 pp. 391-399; Activity 20.1; Animated tutorial
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Apr 28 | Gene Duplication and Molecular Evolution: Hox Genes | Ch. 20 pp. 396-399; Ch. 24 pp. 473-476. C. elegans, Twinned genes |
Apr 30 | Cell Differentiation: Neurulation and organogenesis. QUIZ 10 | Ch. 20 pp. 402-409 |
May 3
|
Ch. 18, pp. 355-356; Ch. 19,
pp. 379-380; Ch. 20 pp. 399-402
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May 5 | Catch-up; Review; Course Evaluation | ------------ |
May 7 | EXAM 4 | ------------ |
May 12 | OPTIONAL COMPREHENSIVE FINAL EXAM AT 6:30 PM | **This is a WEDNESDAY EVENING** |