KAP
Biology Dept
Kenyon College
KAP   Genetics and Development
Fall Section Spring Section 1 Spring Section 2
Syllabus 11:10AM Section 00, Fall 2006
Update December 14, 2006

Dr. Joan Slonczewski, 302 Higley, pbx 5397, slonczewski@kenyon.edu
MWF 11:10 AM in TOM 101 Office Hours: MR 1:00-4:00

Visitors: Please report corrections to course directors.
This course introduces the mechanisms of heredity, the expression of genetic information, and the genetic control of development. Genetics and development are part of a continuous process revealing a fundamental kinship of life.
Required Reading

Biological Science, 2E, by Scott Freeman, 2005
Articles and problems linked to Reading
or provided in class
Download Flowers. (PC only.)  Permission from Schmidel.
Flowers, Mendelian inheritance tutorial
Plasmid, Recombinant plasmid tutorial

Flowers colors:


Recommended sites: Stereo molecules; Biomolecules

How to do well in this course.
  • Attend EVERY class.  Avoid missing more than two classes for sports events or any other reason.
  • Complete all assigned reading by the date assigned on the syllabus.
  • Practice Tutorials & Quizzes.
  • Complete all homework and unannounced quizzes.
  • See Dr. S. Monday or Thursday afternoons between 1:10-4:00, or email appointment.
  • Attend review sessions held before tests
  • E-mail your instructor if you want to discuss anything. 
  • Be aware that fraternity activities, especially work project week, are associated with poor class performance.
Class resources. Web Notes include lecture outline and linked articles. Stereo molecules may be viewed with Pokescope viewer. To obtain your own, see Dr. S.

Grades.  Grades are based on:

  • 60% -- Four one-hour tests. Lowest grade dropped, for students who missed no more than two classes.
  • 20% -- Homework and unannounced quizzes.  The lowest grade will be dropped, or one missed quiz will be excused.
  • 20% -- Final exam (2 hours) is required..
Academic Honesty.  This class will follow the official Kenyon College position on academic honesty. It is your responsibility to review the official College policy on academic honesty and adhere to this policy. 

Learning Disabilities. The College will make reasonable accommodations for persons with documented disabilities.  Students must notify the Coordinator for Students with Disabilities, Erin Salva (located in the Old Bank Building) and their instructors of any special needs. Instructors must be notified sometime during the first two weeks of class.

Sports activities.  If your sport events conflict with class, inform the instructor in writing ahead of time.  Up to two conflicts are allowed without attendance penalty.  Work due must be turned in ahead of the conflict date.

Homework policy:
All homework is turned in before class, printed out and stapled.
Late work loses points, or is not accepted.

Lecture Schedule
DATE TOPIC READING . . . (KC links work only at Kenyon)
AUG 28

AUG 30

SEP 1

History of Genetics; Genes and genomes; Sizes

Stereo MoleculesDNA Structure; Ligers; Try

DNA Replication


Ch. 4; Z-DNAKC

Sec. 14.1-14.4

SEP 4

SEP 6

SEP 8

Chromosome structure. Harlequin.

Cell Division 

Mendelian inheritance; Mendel's Peacocks

Sec. 18.2; Chromosomes

Sec. 11.1-11.2; Ch. 12

Ch. 13; Download Flowers

SEP 11

SEP 13

SEP 15

Sex determinationPractice Medical Pedigrees

Dihybrid. Epistasis--Gene product interaction

Recombination and mapping. Human recomb.KC

Homework 1. ##Y chromosomeKC

---

Linkage

SEP 18

SEP 20

SEP 22

Nonmendelian inheritanceFragile X

TEST 1

Transcription of DNA to RNA. Transcription; PKU

Mitochondrial DNA; Imprinting

Test 1 Practice Problems

Sec. 16.1-16.2

SEP 25

SEP 27

SEP 29

Genetic code and Translation.  More Translation.
Polysome. Transfer RNA Serine
Translation by the ribosome Protein Dance

Eukaryotic transcription and Splicing; Spliceosome

Sec. 16.3-end (Essay)

TBA

Eukaryotic gene expression

OCT 2

OCT 4

OCT 6

DNA Mutation and repair  Cleft palate; Cleft; Nobel

Cell Cycle and Cancer Kornberg Nobel

The Immune system 

Sec. 14.5-end; SUMO mutation KC

Homework 2; Key.
Ch. 8, pp. 155-158 and 164-173
Dr. Luse, "RNA Polymerase"

Ch. 49

OCT 9

OCT 11

OCT 13

OCTOBER READING DAYS

Bacterial gene transfer

Bacterial Genomes

---

Bacterial genetics 

Ch. 20

OCT 16

OCT 18

OCT 20

TEST 2

Molecular Evolution; Gene families (Prof. Powell) 

Genes in evolution. Problems 1-3 .

Test 2 Practice Problems

Ch. 24

Hox genes KC

OCT 23

OCT 25

OCT 27

Jumping genes; Transposons

Recombinant DNA and PCR; Gene cloning

Hybridization and transgenics

Transposons

Ch. 19

---

OCT 30

NOV 1

NOV 3

Human Genome
Prokaryotic gene expression
: Operons
Global regulons: DNA Chip; Proteomics

Eukaryotic transcriptional activation; Euk

Ch. 17

Homework 3.

"The Preeclampsia Puzzle" handout

NOV 6

NOV 8

NOV 10

Transcription factors

Post-transcriptional regulation.

TEST 3.

Ch. 18

Optional practice: Biomorph 6

Test 3 Practice Key Test Key

NOV 13

NOV 15

NOV 17

Microbial development
Developmental communities: Biofilms
Concepts in Development

Gamete Production and Fertilization.

Endospores

Development

 
THANKSGIVING BREAK
 
NOV 27

NOV 29

DEC 1

Drosophila Development; Model Systems

Pattern formation Proboscipedia

Plant development; Flower development

Ch. 48

TBA

Ch. 40

DEC 4

DEC 6

DEC 8

Cleavage and Gastrulation Movies

Neurulation and Limb DevelopmentMovie
Neurulation

Human reproduction Human cloning

Homework 4.

Hox genesKC

Stem Cells and Cloning?

DEC 11

TEST 4.

Test 4 Practice
Test 4 Key

DEC 15
FINAL EXAM -- 8:30AM