BIOL 114 Genetics and Development

KAP
Biology Dept
Kenyon College

KAP Genetics and Development

Syllabus 11:10AM Section 00, Fall 2006
Update December 14, 2006

Dr. Joan Slonczewski, 302 Higley, pbx 5397, slonczewski@kenyon.edu
MWF 11:10 AM in TOM 101 Office Hours: MR 1:00-4:00

Visitors: Please report corrections to course directors.

This course introduces the mechanisms of heredity, the expression of genetic information, and the genetic control of development. Genetics and development are part of a continuous process revealing a fundamental kinship of life.

Required Reading

Biological Science, 2E, by Scott Freeman, 2005
Articles and problems linked to Reading or provided in class
Download Flowers. (PC only.) Permission from Schmidel.
Flowers, Mendelian inheritance tutorial
Plasmid, Recombinant plasmid tutorial

Flowers colors:

Recommended sites: Stereo molecules; Biomolecules

How to do well in this course.

Attend EVERY class. Avoid missing more than two classes for sports events or any other reason.
Complete all assigned reading by the date assigned on the syllabus.
Practice Tutorials & Quizzes.
Complete all homework and unannounced quizzes.
See Dr. S. Monday or Thursday afternoons between 1:10-4:00, or email appointment.
Attend review sessions held before tests.
E-mail your instructor if you want to discuss anything.
Be aware that fraternity activities, especially work project week, are associated with poor class performance.

Class resources. Web Notes include lecture outline and linked articles. Stereo molecules may be viewed with Pokescope viewer. To obtain your own, see Dr. S.

Grades. Grades are based on:

60% -- Four one-hour tests. Lowest grade dropped, for students who missed no more than two classes.
20% -- Homework and unannounced quizzes. The lowest grade will be dropped, or one missed quiz will be excused.
20% -- Final exam (2 hours) is required..

Academic Honesty. This class will follow the official Kenyon College position on academic honesty. It is your responsibility to review the official College policy on academic honesty and adhere to this policy.

Learning Disabilities. The College will make reasonable accommodations for persons with documented disabilities. Students must notify the Coordinator for Students with Disabilities, Erin Salva (located in the Old Bank Building) and their instructors of any special needs. Instructors must be notified sometime during the first two weeks of class.

Sports activities. If your sport events conflict with class, inform the instructor in writing ahead of time. Up to two conflicts are allowed without attendance penalty. Work due must be turned in ahead of the conflict date.

Homework policy:
All homework is turned in before class, printed out and stapled.
Late work loses points, or is not accepted.

Lecture Schedule

DATE	TOPIC	READING . . . (KC links work only at Kenyon)
AUG 28 AUG 30 SEP 1	History of Genetics; Genes and genomes; Sizes Stereo Molecules; DNA Structure; Ligers; Try DNA Replication	Ch. 4; Z-DNAKC Sec. 14.1-14.4
SEP 4 SEP 6 SEP 8	Chromosome structure. Harlequin. Cell Division Mendelian inheritance; Mendel's Peacocks	Sec. 18.2; Chromosomes Sec. 11.1-11.2; Ch. 12 Ch. 13; Download Flowers
SEP 11 SEP 13 SEP 15	Sex determination. Practice Medical Pedigrees Dihybrid. Epistasis--Gene product interaction Recombination and mapping. Human recomb.KC	Homework 1. ##Y chromosomeKC --- Linkage
SEP 18 SEP 20 SEP 22	Nonmendelian inheritance. Fragile X TEST 1 Transcription of DNA to RNA. Transcription; PKU	Mitochondrial DNA; Imprinting Test 1 Practice Problems Sec. 16.1-16.2
SEP 25 SEP 27 SEP 29	Genetic code and Translation. More Translation. Polysome. Transfer RNA Serine Translation by the ribosome Protein Dance Eukaryotic transcription and Splicing; Spliceosome	Sec. 16.3-end (Essay) TBA Eukaryotic gene expression
OCT 2 OCT 4 OCT 6	DNA Mutation and repair Cleft palate; Cleft; Nobel Cell Cycle and Cancer Kornberg Nobel The Immune system	Sec. 14.5-end; SUMO mutation KC Homework 2; Key. Ch. 8, pp. 155-158 and 164-173 Dr. Luse, "RNA Polymerase" Ch. 49
OCT 9 OCT 11 OCT 13	OCTOBER READING DAYS Bacterial gene transfer Bacterial Genomes	--- Bacterial genetics Ch. 20

OCT 16 OCT 18 OCT 20	TEST 2 Molecular Evolution; Gene families (Prof. Powell) Genes in evolution. Problems 1-3 .	Test 2 Practice Problems Ch. 24 Hox genes KC
OCT 23 OCT 25 OCT 27	Jumping genes; Transposons Recombinant DNA and PCR; Gene cloning Hybridization and transgenics	Transposons Ch. 19 ---
OCT 30 NOV 1 NOV 3	Human Genome Prokaryotic gene expression: Operons Global regulons: DNA Chip; Proteomics Eukaryotic transcriptional activation; Euk	Ch. 17 Homework 3. "The Preeclampsia Puzzle" handout
NOV 6 NOV 8 NOV 10	Transcription factors Post-transcriptional regulation. TEST 3.	Ch. 18 Optional practice: Biomorph 6 Test 3 Practice Key Test Key
NOV 13 NOV 15 NOV 17	Microbial development Developmental communities: Biofilms Concepts in Development Gamete Production and Fertilization.	Endospores Development
	THANKSGIVING BREAK
NOV 27 NOV 29 DEC 1	Drosophila Development; Model Systems Pattern formation Proboscipedia Plant development; Flower development	Ch. 48 TBA Ch. 40
DEC 4 DEC 6 DEC 8	Cleavage and Gastrulation Movies Neurulation and Limb DevelopmentMovie Neurulation Human reproduction Human cloning	Homework 4. Hox genesKC Stem Cells and Cloning?
DEC 11	TEST 4.	Test 4 Practice Test 4 Key
DEC 15	FINAL EXAM -- 8:30AM